First Patient dosed in Ph 1 Trial of Padeliporfin VTP in Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma (PDAC)
“Dosing the first patient in this trial is an important milestone for ImPact and the clinical advancement of Padeliporfin VTP as we seek to extend promising observations from ENLIGHTED, our ongoing pivotal study in low-grade upper tract urothelial carcinoma, into patients with locally advanced PDAC,” said Dr. Eyal Morag, Chief Medical Officer of ImPact Biotech. “PDAC is among the most challenging malignancies to treat, particularly where surgical intervention is not a viable option. The ability to undergo a Whipple procedure following treatment with Padeliporfin VTP, as has occurred with this first patient, underscores the potential of our platform to not only induce meaningful tumor regression but also open the door for curative surgical interventions for previously inoperable disease.” The ongoing Phase 1 trial is a two-part, multicenter, nonrandomized, open-label clinical study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of Padeliporfin VTP therapy, as defined by the ability to convert inoperable patients to eligible for resection, in patients with Stage III, locally advanced, unresectable PDAC. The trial is actively enrolling in UCI Irvine Medical Center and City of Hope Medical Center.
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