Conference Coverage: European Society for Medical Oncology Congress

ESMO 2025

  1. AdvanCell’s 212Pb-ADVC001 demonstrates encouraging safety and compelling anti-tumor activity in Ph 1b in prostate cancer
  2. Akeso Inc. presents data from the registrational Ph 3 AK112-306/HARMONi-6 study of ivonescimab in 1L sq-NSCLC
  3. Antengene Presents ATG-022 Clinical data Demonstrating Efficacy Across All CLDN18.2 Expression Levels and Exceptional Tolerability
  4. Artios Announces Ph 1/2a Data for ART6043
  5. Arvinas Presents Data from the Vepdegestrant Clinical Development Program
  6. Avacta Therapeutics presents compelling Ph 1a data for faridoxorubicin and the pre|CISION® platform
  7. BioAtla Presents Interim Data from Ph 1 Trial with BA3182 in Patients with Treatment Refractory Metastatic Adenocarcinoma
  8. Boehringer’s zongertinib demonstrated a 77% ORR in 1L HER2 (ERBB2)-mutant NSCLC
  9. BPGbio Presents Ph 2 Glioblastoma Data on BPM31510
  10. BriaCell Presents Positive Clinical Biomarker Data of Ph 3 Study of Bria-IMT™ in metastatic breast cancer (MBC)
  11. CARsgen Presents Preliminary Results on Satri-cel for Adjuvant Therapy of Pancreatic Cancer
  12. Celcuity Presents Updated Data from Ph 1 Study Evaluating Gedatolisib Plus Darolutamide in Men with mCRPC
  13. Corbus Pharmaceuticals Presents CRB-701 Robust Clinical Responses in HNSCC and Cervical Cancers
  14. Corvus Pharmaceuticals Announces Presentation of Interim Data from the Ph 1b/2 Trial of Ciforadenant for Patients with Metastatic RCC
  15. CStone Discloses Ph 1 Data for CS2009
  16. DATROWAY + Rilvegostomig Showed Promising Tumor Responses in Patients with Metastatic Urothelial Cancer in TROPION-PanTumor03 Ph 2 Trial
  17. Datroway demonstrated an unprecedented median OS improvement of five months vs. chemo as 1L treatment for patients with mTNBC for whom immunotherapy was not an option in TROPION-Breast02
  18. Disitamab Vedotin Achieves Major Breakthrough as First-Line Treatment for Urothelial Carcinoma
  19. DS-3939 Shows Promising Preliminary Clinical Activity in Patients with Advanced Solid Tumors in Ph 1/2 Trial
  20. Eikon Therapeutics to Present New Ph 2 Data on EIK1001 in 1L NSCLC
  21. Enhertu followed by THP before surgery resulted in a pCR in 67% of patients with high-risk HER2-positive early-stage breast cancer in DESTINY-Breast11 Ph 3 trial
  22. Enhertu reduced the risk of disease recurrence or death by 53% vs. T-DM1 in patients with high-risk HER2-positive early breast cancer following neoadjuvant therapy in DESTINY-Breast05 Ph 3 trial
  23. Evaxion reports 75% ORR in Ph 2 trial with AI-designed personalized cancer vaccine EVX-01
  24. Exelixis Announces Detailed Results from Ph 3 STELLAR-303 Pivotal Trial of Zanzalintinib in Combination with an Immune Checkpoint Inhibitor in mCRC
  25. General Oncology Announces Promising Preliminary Ph 1 Results from SHARON Trial
  26. Genmab Announces New Data Demonstrating Investigational Rinatabart Sesutecan (Rina-S®) Achieved Anti-Tumor Activity in Heavily Pretreated Patients with Advanced Endometrial Cancer
  27. Hansoh Pharma Announces Proffered Paper Presentation of Ph 2 Study on HS-20093 in R/R Sarcomas
  28. Hansoh Pharma Presents the Ph 2 study findings of HS-20089 (B7-H4-targeted ADC), in patients with platinum-resistant ovarian cancer (PROC)
  29. HUTCHMED Highlights FRUSICA-2 Registration Trial Data
  30. IDEAYA Biosciences Announces Positive Ph 2 Data for Darovasertib in the Neoadjuvant Setting of Primary Uveal Melanoma
  31. Imfinzi-based regimen reduced the risk of death by 22% in early gastric cancer vs. chemotherapy alone in MATTERHORN Ph 3 trial
  32. Imfinzi regimen reduced the risk of disease recurrence or death by 32% in high-risk NMIBC in the POTOMAC Ph 3 trial
  33. Immatics Highlights Compelling Anti-Tumor Activity of Anzu-cel PRAME Cell Therapy in Metastatic Uveal Melanoma
  34. IMUNON to Present Ph 3 Ovarian Cancer Study of IMNN-001
  35. ImmunOs Therapeutics Reports Promising Clinical Activity of IOS-1002 in Advanced Solid Tumors
  36. Incyte Announces Ph 1 Results for TGFβR2×PD-1 Bispecific Antibody in Advanced CRC and KRAS G12D Inhibitor in Advanced Pancreatic Ductal Adenocarcinoma
  37. IO Biotech Presents Ph 3 Results for Cylembio + KEYTRUDA in 1L Advanced Melanoma
  38. iOnctura presents cambritaxestat (IOA-289) clinical data in patients with pancreatic cancer
  39. ITM Announces Ph 3 COMPETE Data Demonstrating a Statistically Significant Higher ORR with n.c.a. 177Lu-edotreotide (ITM-11) vs. Everolimus in Patients with GEP-NETs
  40. Ivonescimab + Chemo Reduced the Risk of Disease Progression or Death by 40% vs Tislelizumab + Chemo in 1L Squamous NSCLC in the HARMONi-6 Study 
  41. Kelun-Biotech Presents Positive Ph 3 Data for Trastuzumab Botidotin Compared to T-DM1 
  42. KEYTRUDA® Demonstrates Long-Term Survival Benefit in Certain Patients With Earlier or Advanced Stages of NSCLC
  43. KEYTRUDA® + Chemo With or Without Bevacizumab Reduced Risk of Disease Progression or Death Versus Chemotherapy With or Without Bevacizumab in Certain Patients With Platinum-Resistant Recurrent Ovarian Cancer
  44. KEYTRUDA® + Padcev® (enfortumab vedotin-ejfv) Reduced Risk of EFS Events by 60% and Risk of Death by 50% for Certain Patients with MIBC When Given Before and After Surgery
  45. KEYTRUDA® + LENVIMA® (lenvatinib) Demonstrates Durable 5-Year Survival Benefit Versus Chemo for Patients With Advanced Endometrial Carcinoma Following One Prior Platinum-Based Regimen
  46. Kura Oncology Announces Preliminary Data from Its Farnesyl Transferase Inhibitor (FTI) Programs
  47. Leap Therapeutics Presents Final Data from DeFianCe Study
  48. Lilly’s Verzenio® (abemaciclib) prolonged survival in HR+, HER2-, high-risk early breast cancer with two years of treatment
  49. Mabwell Announces Latest Clinical Results of Novel B7-H3-Targeting ADC 7MW3711
  50. Marengo Presents Initial Ph 2 Results Demonstrating Broad Single-Agent Activity of Invikafusp Alfa Across Multiple PD-1-Refractory or -Resistant Solid Tumors
  51. Merck Announces Ph 3 KEYNOTE-B96 Trial Met Secondary Endpoint of OS in All Comers Population of Patients With Platinum-Resistant Recurrent Ovarian Cancer
  52. Moderna announced clinical, safety and translational data from Ph 1/2 study of mRNA-4359 + pembrolizumab in CPI-R/R melanoma patients
  53. Multitude Therapeutics Announces Interim Ph 1/2 AMT-253 trial in Melanoma and Other Advanced Solid Tumors
  54. New AlphaMedix data showed sustained and clinically meaningful responses across both RLTnaïve and RLT-exposed patients with unresectable or metastatic GEP-NETs
  55. New safety and PK data from Ph 3 C-POST trial provide insights on an every 6-week dosing regimen of adjuvant Libtayo® (cemiplimab) in high-risk CSCC
  56. Nouscom Presents Positive Ph 2 Results of NOUS-209 Combined with Pembrolizumab in MSI-H mCRC Patients Refractory to Anti-PD-1 Therapy
  57. Novartis Kisqali® 5-year NATALEE data demonstrate 28% reduction in risk of recurrence in the broadest early breast cancer patient population
  58. Nurix Therapeutics Reports New Clinical Data from NX-1607, Demonstrating Single-Agent Activity Across Multiple Tumor Types
  59. Nuvalent Presents Preliminary Data for Neladalkib in Advanced ALK-positive Solid Tumors Beyond NSCLC
  60. Olema Oncology Announces New Data from the Ph 1b/2 Trial of Palazestrant Plus Ribociclib in ER+/HER2- Metastatic Breast Cancer
  61. Patient-Reported Outcomes from VERITAC-2 Trial Support Clinical Benefit of Vepdegestrant in Patients with ESR1-Mutated, ER+/HER2- Advanced or Metastatic Breast Cancer Previously Treated with Endocrine-Based Therapy
  62. Perspective Therapeutics Presents Updated Interim Data from Ongoing Ph 1/2a Trial of [212Pb]VMT-α-NET
  63. Positive Results from Ph 3 OptiTROP-Lung04 Trial of Sacituzumab Tirumotecan presented
  64. Primary Endpoint Met in EFTISARC-NEO Ph 2 of Neoadjuvant Efti in Soft Tissue Sarcoma and Data Presented
  65. PSMAddition data show Novartis Pluvicto™ delays progression to end-stage prostate cancer
  66. Raludotatug Deruxtecan Demonstrated Clinically Meaningful Response Rates in Patients with Recurrent Platinum-Resistant Ovarian, Primary Peritoneal or Fallopian Tube Cancer in Ph 2 Part of REJOICE-Ovarian01 Ph 2/3 Trial
  67. Relacorilant Demonstrates Benefit in Patients with Platinum-Resistant Ovarian Cancer with Prior PARP Inhibitor Treatment
  68. Replimune Highlights Acral Melanoma Data for RP1 plus Nivolumab
  69. Roche’s Tecentriq showed significant OS and DFS benefits in bladder cancer with ctDNA-guided treatment
  70. Roche’s Ph 2 evERA data showed giredestrant significantly improved PFS in people with ER-positive advanced breast cancer
  71. SC amivantamab delivers promising 45% ORR with median duration of 7.2 months in recurrent or metastatic head and neck cancer
  72. SCG announces presentation of clinical results of SCG142 in patients with HPV-related carcinoma
  73. Sensei Biotherapeutics Reports New Clinical Results Highlighting Durable PFS Data for Solnerstotug in PD-(L)1 Resistant Tumors
  74. Significant OS Benefit with Cadonilimab in 1L Advanced Gastric Cancer: Final Analysis of COMPASSION-15 Presented
  75. SystImmune, Inc. and BMS Announce First Global Ph 1 Results of Iza-bren in Patients with Advanced Solid Tumors
  76. Taiho Oncology and Cullinan Therapeutics Present Data on Zipalertinib in Patients with NSCLC with EGFR Mutations and Active Brain Metastases
  77. Theolytics to Present Ongoing Ph 1/2a OCTOPOD-IV Trial of THEO-260 in Ovarian Cancer
  78. TOLREMO therapeutics Completes First In Human Dose Escalation for TT125-802 and Presents Solid Tumor Monotherapy
  79. Transgene and BioInvent’s Armed Oncolytic Virus BT-001 Shows Positive Local, Abscopal, and Sustained Antitumoral Activity in Advanced Refractory Tumors
  80. Trodelvy® Reduces Risk of Disease Progression or Death by 38% Versus Chemo as 1L Therapy in Patients With mTNBC in ASCENT-03 Study
  81. Tubulis Presents First Clinical Data from Ph 1/2a Trial for TUB-040 in Platinum-Resistant Ovarian Cancer (PROC)

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