First-in-Human Data from Ph 1 Trial of GTA182 in MTAP-Deleted Advanced NSCLC presented
“We are pleased to share the first clinical data for GTA182, which demonstrate strong target engagement, early tumor responses, and encouraging signs of intracranial activity in patients with MTAP-deleted advanced solid tumors,” said Mingxi Li, Ph.D., Chief Executive Officer of Apeiron Therapeutics. “These results highlight GTA182’s differentiated profile as a brain-penetrant, MTA-cooperative PRMT5 inhibitor designed specifically for MTAP-deleted tumors. The emerging safety, PK/PD, and antitumor activity data support continued dose exploration and advancement toward expansion cohorts.”
Share:
More News
“From the outset, our goal has been to build a discovery engine that systematically unlocks high-value, challenging targets and delivers first-in-class precision medicines,” said Adam Friedman, M.D., Ph.D., Chief Executive Officer of Antares. “This collaboration lets us scale that engine alongside Novartis’ world-class development capabilities and global reach, so we
“We are very pleased that the iDMC has recommended continuation of the landmark OVATION 3 clinical trial without modification, representing another important validation of the remarkable efficacy and safety data previously reported and further indicating the potential for IMNN-001 to represent a historic advance in the treatment of ovarian cancer,”
“VS-7375 has demonstrated anti-tumor activity across multiple dose levels and tumor types, encouraging signals from rational combination strategies, and a favorable safety profile that improves meaningfully beyond the first treatment cycle, underscoring its potential to be not only the best-in-class oral KRAS G12D inhibitor, but also the preferred treatment option
“We are pleased that the FDA has demonstrated urgency in reconsidering the RP1 BLA with an expeditious action date in recognition of the significant unmet need for advanced melanoma patients and support from the broader melanoma community,” said Sushil Patel, Ph.D., CEO of Replimune. “We look forward to a productive