Encouraging Clinical Results with In Situ Conversion Therapy NXL-004 for Malignant Glioma Reported
In the patient receiving intratumoral injection, a clear therapeutic response was observed, with target lesion shrinkage exceeding 90%. In one patient treated with tumor resection followed by intracavitary injection of NXL-004, postoperative imaging demonstrated progressive tumor reduction leading to complete radiographic disappearance, achieving a complete response (CR). The results demonstrate that NXL-004 exhibits both a favorable safety profile and promising clinical efficacy, validating the feasibility and therapeutic potential of in situ conversion therapy in the treatment of glioma.
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