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European Society for Medical Oncology Congress

ESMO 2023

  1. 100% Disease Control in 2L NSCLC Demonstrating Impressive Positive Preliminary Efficacy Data for Ongoing THIO-101 Phase 2 Trial
  2. Alecensa Reduces the Risk of Disease Recurrence or Death by an Unprecedented 76% in People With ALK-Positive Early-Stage NSCLC
  3. Bolt Biotherapeutics to Present New Clinical Data from Completed Phase 1/2 Dose-Escalation Trial of BDC-1001 in HER2-Expressing Solid Tumors
  4. Botensilimab/Balstilimab Combination Delivers Durable Responses Across Multiple Sarcoma Subtypes
  5. Data for Luveltamab Tazevibulin (luvelta) from the Phase 1 Dose-Expansion Study presented
  6. Datopotamab deruxtecan significantly extended PFS vs. chemo in patients with HR-positive, HER2-low/neg breast cancer in TROPION-Breast01 Phase III trial
  7. Datopotamab deruxtecan improved PFS vs. chemotherapy in patients with previously treated NSCLC in TROPION-Lung01 Phase III trial
  8. Datopotamab deruxtecan + Imfinzi demonstrated robust and durable tumour responses in 1L treatment of patients with mTNBC in BEGONIA Phase Ib/II trial
  9. Detailed Results from Phase 3 CABINET Pivotal Trial Evaluating Cabozantinib in Advanced Neuroendocrine Tumors Presented
  10. ENHERTU® (fam-trastuzumab deruxtecan-nxki) demonstrated clinically meaningful survival across multiple HER2-expressing advanced solid tumors in DESTINY-PanTumor02 Phase II trial
  11. Final Multivariate Analysis from the Phase 3 MAGNITUDE Study Shows Trend Toward Improvement in OS in Patients with mCRPC with BRCA Alterations Treated with Niraparib and Abiraterone Acetate Plus Prednisone
  12. First Results with Erdafitinib-Releasing Intravesical Delivery System (TAR-210) Show Early Evidence of Positive Clinical Activity in Patients with NMIBC with Select FGFR Alterations
  13. Gilead And Kite Oncology Present Important New Data Across Multiple Difficult-To-Treat Cancers 
  14. HOOKIPA Pharma Presents Additional Preliminary Phase 2 Data on HB-200 in Combination with Pembrolizumab as First-Line Treatment in Patients with HPV16+ Head and Neck Cancers
  15. Initial Phase 1 Dose Escalation Data of ORIC-114 in Patients with EGFR and HER2 Exon 20 Mutations Demonstrates Potential Best-In-Class Profile
  16. Imfinzi plus chemotherapy more than doubled pathologic complete response rate in resectable early-stage gastric and GEJ cancers versus chemo alone
  17. Imfinzi plus Lynparza reduced the risk of disease progression or death by 45% vs. chemotherapy in advanced or recurrent endometrial cancer
  18. KEYTRUDA + Chemo Showed Statistically Significant Improvement in pCR Rate as Neoadjuvant Therapy vs Chemo in High-Risk, Early-Stage ER+/HER2- Breast Cancer
  19. KEYTRUDA + Chemo Before Surgery and Continued as Single Agent After Surgery Reduced Risk of Death by 28% Versus Pre-Operative Chemo in Resectable Stage II, IIIA or IIIB NSCLC
  20. KEYTRUDA + Concurrent chemoRT Significantly Improved PFS vs Concurrent chemoRT Alone in Newly Diagnosed, High-Risk Locally Advanced Cervical Cancer
  21. KEYTRUDA + Padcev Reduced Risk of Death by More Than Half vs Chemo in Patients With 1L Locally Advanced or Metastatic Urothelial Cancer
  22. KEYTRUDA + Trastuzumab and Chemo Significantly Improved PFS Versus Trastuzumab & Chemo in 1L HER2+ve Advanced GEJ Adenocarcinoma
  23. Kisqali® NATALEE analysis reinforces consistent reduction in risk of recurrence across key subgroups of patients with early breast cancer
  24. Landmark 5-Year monarchE Outcome Data Demonstrate Verzenio® (abemaciclib)’s Long-Term Impact on Cancer Recurrence in High-Risk Early Breast Cancer
  25. Libtayo (cemiplimab) Neoadjuvant Treatment Demonstrates Encouraging EFS in Patients with Resectable CSCC
  26. Neoadjuvant Opdivo + Chemo Provides Benefits for Patients with Resectable NSCLC Across PD-L1 expression levels with 3-Year follow Up in CheckMate-816 Trial
  27. New And Updated Botensilimab Data In Colorectal, Pancreatic, Lung, Melanoma, And Sarcoma presented
  28. New Data from Phase 3 PAPILLON Study Show RYBREVANT® (amivantamab-vmjw) + Chemo Resulted in 60% Reduction in Risk of Disease Progression or Death in Patients with Previously Untreated EGFR Exon 20 Insertion Mutation-Positive NSCLC
  29. New Lumakras (Sotorasib) + Vectibix (Panitumumab) Data In Patients With KRAS G12C-Mutated mCRC presented
  30. New Tarlatamab Data In SCLC presented
  31. Olema Oncology Announces Positive Phase 2 Monotherapy Clinical Study Results for Palazestrant
  32. Opdivo + Cisplatin-Based Chemo Followed by Opdivo Demonstrates Significant Survival Benefits for Cisplatin-Eligible Patients with Unresectable or Metastatic Urothelial Carcinoma in Phase 3 CheckMate -901 Trial
  33. Potential of Arvinas’ PROTAC® AR Degraders Reinforced by 11.1 months rPFS with Bavdegalutamide & Updated Positive Interim Data from 2nd gen ARV-766 in mCRPC
  34. Perioperative Regimen of Neoadjuvant Opdivo & Chemo Followed by Adjuvant Opdivo Shows Significant Improvement in EFS for Patients with Resectable NSCLC in Phase 3 CheckMate -77T Trial
  35. Phase 3 MARIPOSA Study Shows RYBREVANT® (amivantamab-vmjw) Plus Lazertinib Resulted in 30 Percent Reduction in Risk of Disease Progression or Death Compared to Osimertinib in Patients with EGFR-Mutated NSCLC
  36. Phase 3 MARIPOSA-2 Study Shows RYBREVANT (amivantamab-vmjw) Plus Chemotherapy Given with or without Lazertinib Reduced Risk of Disease Progression or Death by 56% and 52% in Patients with EGFR-Mutated NSCLC who Progressed on or after Osimertinib
  37. Phase 3 RATIONALE 315 Trial Met Primary Endpoints of Major Pathological Response Rate and EFS for Tislelizumab + Chemo in Patients with Resectable NSCLC
  38. Pluvicto™ Shows Clinically Meaningful And Highly Statistically Significant rPFS Benefit In Patients With PSMA-Positive mCRPC In The Pre-Taxane Setting
  39. Raludotatug Deruxtecan Continues to Demonstrate Promising Clinical Activity in Patients with Advanced Ovarian Cancer in Early Trial 
  40. Results Evaluating the Combination of Adagrasib and Pembrolizumab in 1L NSCLC presented
  41. Results from Phase 2 THOR-2 Study Show Improved Rates of RFS in Patients with High-Risk NMIBC with Select FGFR Alterations Treated with BALVERSA® (erdafitinib) Vs Chemo
  42. Retevmo® (selpercatinib) Phase 3 Results in RET Fusion-Positive NSCLC and RET-Mutant Medullary Thyroid Cancer Both Published in The NEJM and Presented
  43. Tagrisso plus chemo reduced the risk of disease progression in the brain by 42% in patients with EGFR-mutated advanced lung cancer and brain mets at baseline
  44. TAR-200 Intravesical Delivery System Results Show 77 Percent CRR in Patients with BCG Unresponsive, High-Risk NMIBC
  45. Tislelizumab + chemo Significantly Improved OS at Final Analysis in 1L Advanced Gastric or GEJ
  46. TIVDAK® (tisotumab vedotin-tftv) Significantly Prolonged OS in Patients with Recurrent/Metastatic Cervical Cancer vs Chemo in Phase 3 innovaTV 301 Trial
  47. WELIREG® (belzutifan) Significantly Improved PFS and ORR Versus Everolimus in Certain Previously Treated Patients With Advanced RCC

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