FDA IND Clearance for ARR-002 in Ovarian and Endometrial Cancers
“We are pleased to advance ARR-002 into the clinic as the second next-generation ADC from our portfolio,” said Stuart Lutzker, MD, Ph.D., President of Research and Development of ArriVent. “At AACR, compelling preclinical data was presented demonstrating ARR-002’s potential to improve safety and efficacy over conventional single-target and bivalent bispecific ADCs in ovarian and endometrial cancers. ARR-002’s dual-target approach is designed to improve delivery and reduce off-tumor toxicity to overcome key limitations of single-target ADCs, including limited internalization, suboptimal payload delivery, and heterogeneous target expression. We expect to initiate a Phase 1 trial and dose the first patient in the second half of the year.”
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