First-in-Human Data from Ph 1 Trial of GTA182 in MTAP-Deleted Advanced NSCLC presented
“We are pleased to share the first clinical data for GTA182, which demonstrate strong target engagement, early tumor responses, and encouraging signs of intracranial activity in patients with MTAP-deleted advanced solid tumors,” said Mingxi Li, Ph.D., Chief Executive Officer of Apeiron Therapeutics. “These results highlight GTA182’s differentiated profile as a brain-penetrant, MTA-cooperative PRMT5 inhibitor designed specifically for MTAP-deleted tumors. The emerging safety, PK/PD, and antitumor activity data support continued dose exploration and advancement toward expansion cohorts.”
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