First Patient Dosed in Expansion Cohorts of Ph 1/2 SOLARA Trial of BH-30643 in Advanced EGFRm NSCLC
“The increasing diversity of EGFR mutations has led to a growing number of therapeutic agents targeting various, narrowly defined subsets of EGFR mutation-positive lung cancer. When designing BH-30643, we pursued a different and broader ambition – a highly potent drug capable of inhibiting a wide spectrum of EGFR mutations, while sparing inhibition of wildtype EGFR and HER2, expected to provide a significant survival benefit and a better tolerated therapy for more patients,” said J. Jean Cui, Ph.D., President and Chief Executive Officer of BlossomHill Therapeutics. “With this goal top of mind, we sought to break away from the entrenched thinking present in prior generations of EGFR inhibitor designs. With BH-30643, we seek to address the ongoing unmet medical need for this disease in a safe and effective manner, and we are committed to the rapid advancement of our OMNI-EGFRTM inhibitor in the clinic.”
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