First Patient dosed in Ph 1/2 EVEREST-2 Study with A2B543 in solid tumors
“Dosing the first patient with A2B543 is a significant step forward in the evolution of the Tmod™ platform,” said John Welch, M.D., Ph.D., chief medical officer of A2 Bio. “While systemic IL-12 induces a potent antitumor immune response, its use has been limited by severe toxicity. With A2B543, we are arming our Tmod™ cells with a membrane-tethered, inducible IL-12 component. This design allows us to localize the impact of IL-12 to the tumor microenvironment, boosting the persistence and potency of Tmod™ without the systemic side effects.”
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