First Patient Dosed in Ph 1 Trial of SHY-ONC6 for the Treatment of Solid Tumors
“SHY-ONC6 targets the ubiquitin-proteasome system, which governs the degradation of damaged or unneeded proteins. Unlike current FDA-approved proteasome inhibitors that target the 20S Core Particle, SHY-ONC6 inhibits the ATPases within the 19S Regulatory Particle of the proteasome, introducing a novel and differentiated mechanism of proteasome inhibition,” said Yaron Hadari, Ph.D., SHY’s Chief Executive Officer and Co-Founder.
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