MiNK Therapeutics and Autonomous Therapeutics Announce Collaboration to Develop Novel Therapies Targeting Metastatic Tumors

“This collaboration underscores the unique potential of both native and engineered iNKT cells, allowing us to explore cutting-edge approaches that could significantly enhance clinical responses and deliver better outcomes for patients,” said Dr. Jennifer Buell, President and Chief Executive Officer at MiNK. “MiNK-215 and agenT-797 are novel cell therapies designed to overcome the limitations of traditional immune checkpoint inhibitors. Recent preclinical models of MSS colorectal cancer with metastatic liver disease demonstrated that these iNKT cells have the potential to eliminate tumor cells effectively. By combining them with Autonomous Therapeutics’ engineered RNA technology, we are confident that we can unlock even greater therapeutic possibilities and continue advancing our mission to transform the landscape of cell therapy.”

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“We are pleased to evaluate the clinical combination of IDE892 with RG6505 in MTAP-deleted RAS-mutant PDAC,” said Yujiro S. Hata, President and Chief Executive Officer, IDEAYA Biosciences. “This collaboration aligns with our broader clinical strategy to evaluate rational combinations with assets in our MTAP-deletion portfolio, and there remains especially high

“In the first reported data from the clinical combinations of our PRMT5 inhibitor vopimetostat and RAS(ON) inhibitors, we saw extremely encouraging early results, with 92% of patients with PDAC in the vopimetostat plus daraxonrasib arm achieving an objective response, supporting the preclinical data showing synergistic activity of PRMT5 + RAS

“Non-small cell lung cancer is the most prevalent lung disease with more than 8,000 patients in the U.S. diagnosed each year with KRAS G12D-mutations. Receiving Fast Track designation for VS-7375 reinforces both the significant unmet need and the potential of VS-7375 to improve outcomes for patients with KRAS G12D-mutated lung

“KRAS has notoriously been considered an undruggable target and patients with KRAS-driven cancers continue to face limited treatment options with survival measured in months, not years,” said John Reed, M.D., Ph.D., Executive Vice President, Innovative Medicine, Research & Development, Johnson & Johnson. “We believe the proprietary Firelink™ platform will overcome