Ph 1a data of TOS-358 in heavily pretreated patients with PI3Kα-mutant metastatic breast cancer and other solid tumors presented
“TOS-358 was designed to overcome the limitations of currently available PI3Kα inhibitors by delivering sustained and specific, greater than 90% covalent inhibition of the target combined with a best-in-class safety profile,” said Zelanna Goldberg, M.D., Chief Medical Officer of Totus Medicines. “We are very encouraged by the early clinical efficacy data, which demonstrate durable tumor control and class-leading tolerability in heavily pretreated patients.”
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