Ph 2/3 trial of SIL204 planned in locally advanced pancreatic cancer in Q2 2026
Ilan Hadar, Chairman and Chief Executive Officer of Silexion, commented: “Results from the toxicology studies have cleared us to maintain our planned timelines to initiate SIL204’s Phase 2/3 clinical trial in pancreatic cancer. We have recently secured our CRO partner for the trial and continue to prepare regulatory submissions to both Israel’s Ministry of Health and Germany’s Health Authority (BfArM). SIL204’s preclinical package has shown remarkable potential as a cancer treatment, offering an innovative modality – stopping mutated, cancer-driving proteins before they are expressed. We are eager to prove this potential in the clinic and bring SIL204 to patients who could benefit from this treatment. We remain on track to initiate the first stage of SIL204’s advanced clinical development in the second quarter of 2026.”
Share:
More News
“The designation reinforces the significant unmet need for effective treatment options for patients with advanced breast cancer,” said Charles Baum, M.D., Ph.D., Chief Executive Officer of Terremoto Biosciences. “We are committed to advancing highly selective therapies designed to expand treatment options for patients with difficult to treat cancers.”
“Up to five U.S. clinical sites are planned for THIO-101 Parts C and D this year, and we expect to activate a second U.S. site in the coming weeks,” said Vlad Vitoc, M.D., Founder and Chief Executive Officer of MAIA. “To date, data has shown overall survival (OS) beyond two
Dr. Jason Zhu, Executive Director and Chief Executive Officer of Henlius, said: “The positive CHMP opinion for the sqNSCLC indication marks another important milestone in serplulimab’s regulatory journey in Europe and brings the product one step closer to achieving comprehensive coverage of first-line lung cancer treatment indications in the EU.