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Ph 2 Study of Masofaniten (EPI-7386) + Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer initiated

“Initiation of the randomized Phase 2 portion of this study investigating the combination of masofaniten and enzalutamide (the “Combination”) is a significant milestone for ESSA and we look forward to reporting updated results from the Phase 1 dose equilibration portion of the study next month at ESMO 2023,” stated David Parkinson, M.D., President and CEO of ESSA. “The favorable safety profile observed to date with the Combination has led the safety review board to agree that we can proceed forward into the head-to-head comparison portion of the study with the dose regimen studied in Cohort 4 as our recommended Phase 2 dose. We look forward to further elucidating the Combination’s potential to improve long-term clinical benefit for patients with mCRPC. We plan to provide guidance for timing of the public disclosure of initial data once the Phase 2 portion has been underway for several months.”

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