Serplulimab Achieves 42.5% pCR Rate in Neoadjuvant Colon Cancer
The 2026 European Society for Radiotherapy and Oncology (ESTRO 2026) was held in Stockholm, Sweden, from May 15 to 19 local time. At this conference, Henlius’ innovative anti-PD-1 monoclonal antibody(mAb) serplulimab was officially presented in an oral report for its neoadjuvant therapy study results in locally advanced high-risk colon cancer (LACC). The study was jointly initiated by Professor Sanjun Cai and Professor Zhen Zhang of Fudan University Shanghai Cancer Center. The results showed that radiochemotherapy combined with serplulimab demonstrated favorable efficacy, with the pathological complete response (pCR) rate significantly increased to 42.5%, representing more than a four-fold improvement over the control group. This offers a new treatment option for high-risk LACC and further validates the therapeutic value of serplulimab in the field of gastrointestinal cancers.
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