Serplulimab Achieves 42.5% pCR Rate in Neoadjuvant Colon Cancer
The 2026 European Society for Radiotherapy and Oncology (ESTRO 2026) was held in Stockholm, Sweden, from May 15 to 19 local time. At this conference, Henlius’ innovative anti-PD-1 monoclonal antibody(mAb) serplulimab was officially presented in an oral report for its neoadjuvant therapy study results in locally advanced high-risk colon cancer (LACC). The study was jointly initiated by Professor Sanjun Cai and Professor Zhen Zhang of Fudan University Shanghai Cancer Center. The results showed that radiochemotherapy combined with serplulimab demonstrated favorable efficacy, with the pathological complete response (pCR) rate significantly increased to 42.5%, representing more than a four-fold improvement over the control group. This offers a new treatment option for high-risk LACC and further validates the therapeutic value of serplulimab in the field of gastrointestinal cancers.
Share:
More News
“Pancreatic cancer has historically been one of the most difficult-to-treat cancers and people whose tumors harbor a KRAS G12C mutation face limited options once their disease progresses,” said Jacob Van Naarden, executive vice president, and president of Lilly Oncology. “This Breakthrough Therapy designation reflects the early potential we’re seeing with
“This financing reflects the confidence our investors and strategic partners have in the progress we have made to date and the opportunities that lie ahead,” said Dr. Jack Hoppin, Chief Executive Officer of Ratio Therapeutics. “As we march the ATLAS trial forward and prepare for our 5th IND filing, these
“We are excited to initiate monotherapy expansion evaluating IDE892 in MTAP-deleted PDAC and NSCLC. We designed IDE892 to be a potential best-in-class PRMT5 inhibitor, including approximately 1,400-fold selective MTA-PRMT5 cooperative binding versus SAM-PRMT5 cooperative binding, lack of brain penetrance, and favorable drug-like properties intended to maximize its therapeutic window as
“The data presented at ASCO provided important insight into the potential clinical path for CRB-701 in 2L oropharyngeal cancer, a distinct tumor-type that is on the rise due to HPV infections,” said Yuval Cohen, Ph.D., Chief Executive Officer of Corbus. “Unfortunately, current treatment options have shown limited efficacy underscoring the