Xintela’s oncology subsidiary, Targinta AB, and MSK’s Therapeutics Accelerator to develop integrin α10β1 antibody therapeutic in patients with aggressive sarcoma
Evy Lundgren-Åkerlund, CEO Xintela and Targinta, said, “The collaboration with MSK gives us a fantastic opportunity to clinically develop Targinta’s antibodies, targeting integrin α10β1, together with a leading global cancer center. In preclinical cancer models, we have shown that our lead candidates TARG9, an ADC (Antibody-drug conjugate), and TARG10, a function-blocking antibody, effectively inhibit tumor growth and metastasis of aggressive cancers such as triple-negative breast cancer, glioblastoma and sarcoma. Published results from Dr. Samuel Singer’s research group at MSK (Okada et al, 2016) complement our results and further validate integrin α10β1 as a unique cancer target. This collaboration will now create the opportunity to bring Targinta’s new targeted cancer therapy to patients for the first time. This is a breakthrough for Xintela’s oncology program and a great milestone for our wholly owned subsidiary Targinta.
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