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Zanzalintinib Pivotal Development Program Updates Announced; SCCHN trial discontinued

August 5, 2025

First Patient Dosed in Ph 2 Trial of DOC1021 (dubodencel) for GBM

July 29, 2025

CBX-663 nominated for the treatment of a broad range of solid tumor and heme malignancies

July 29, 2025

First Patient Dosed in Ph 1 Clinical Trial of EGFR-Targeting PRO-XTEN™ Dual-Masked T-Cell Engager VIR-5525 for the Treatment of Solid Tumors

July 29, 2025

First Patient Dosed in COM701 Global Platform Trial in Platinum Sensitive Ovarian Cancer

July 29, 2025

Soft Close to Ph 1 Trial of Oral Gallium Maltolate for R/R GBM Announced

July 29, 2025

ALKAZAR Ph 3 Trial of Neladalkib for Patients with TKI-naïve ALK-positive NSCLC initiated

July 23, 2025

Elraglusib Clinical Program Advanced in Ewing Sarcoma After Positive Ph 1 Trial Demonstrates CRs and PRs in R/R Ewing Sarcoma

July 23, 2025

First Patient Enrolled in Ph 3 AK112-312/HARMONi-GI6 Trial of Ivonescimab for 1L Metastatic CRC

July 23, 2025

First patient dosed in NCI-sponsored pilot study of Pidnarulex (CX-5461) PD in patients with advanced solid tumors

July 23, 2025

Dose Level 1 of ANGELICA TRIAL completed; Proceeding to Dose Level 2 in Patients with Advanced Solid Tumors or Heme Malignancies

July 23, 2025

CRC Cohort of Ph 2 Trial of PDS01ADC Met Criteria for Expansion to Stage 2 Following Positive Stage 1 Results

July 15, 2025

Enrollment completed in Ph 3 UTOPIA Trial of UGN-103 for the Treatment of Recurrent Low-Grade Intermediate-Risk NMIBC

July 15, 2025

First patient dosed in the Ph 1 portion of Ph 1/2 trial of AVZO-1418/DB-1418 in patients with advanced solid tumors

July 15, 2025

First Patient Dosed in Expansion of Ph 2 Trial for Ateganosine in Advanced NSCLC

July 15, 2025

First Patient Dosed in Ph 1/2 Clinical Trial of ETX-636

July 8, 2025

Recruitment Initiated into Expanded Ph 2 Opaganib/Darolutamide Combo Study in Advanced Prostate Cancer

July 8, 2025

First patient dosed in Ph 1a clinical trial for AK146D1

July 8, 2025

Ph 3 Accelerated Approval Trial of IFx-2.0 as an Adjunctive Therapy to Keytruda in 1L Treatment for Advanced or Metastatic MCC initiated

July 1, 2025

First Patient Dosed in Ph 2 Trial of leronlimab in patients with R/R MSS CRC

July 1, 2025

First Patient Dosed with Nectin-4 Targeting ADC CRB-701 in Combination with Pembrolizumab

July 1, 2025

First Patient Dosed with VS-7375 in Ph 1/2a Trial in KRAS G12D Advanced Solid Tumors

July 1, 2025

First Patient Dosed in DENALI-1 Ph 1/2 Clinical Study of A2B395 CAR T Cell Therapy for Patients with EGFR-expressing Solid Tumors 

July 1, 2025

First patient dosed in Ph 1/2 trial of TNG462 and daraxonrasib or zoldonrasib in patients with MTAP-deleted and RAS mutant metastatic pancreatic or lung cancer

July 1, 2025

Second patient dosed in Ph 2 trial protocol of stenoparib in patients with advanced, recurrent, platinum-resistant or platinum-ineligible ovarian cancer

July 1, 2025
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Disclaimer: The OTW team takes care to share authentic information. In case of any discrepancies please write to newsletter@onco-this-week.com. Our website is an aggregator for open-source oncology news. The information on our website is provided without any representations or warranties. OTW is part of RLS Consultants, a global consulting and training firm focusing exclusively on the healthcare and life sciences industries. RLS is a leading provider of opportunity assessment services, utilizing its comprehensive expertise in strategic market research, forecasting, and modeling, as well as pricing and market access to facilitate commercial assessments. RLS does not have any influence on any news reported on OTW. The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of RLS. The content on our website is intended strictly for news and information purposes only and should not be treated as a substitute for medical advice, diagnosis, or treatment. News shared on OTW should not be utilized in real-world analytic products as they are based only on limited and dated open-source information.